Abstract Library

#1465 Assocation Between miRNAs and HDACs in Pancreatic Neuroendocrine Tumors

Introduction: Epigenetic factors are essentially involved in carcinogenesis, tumor promotion and chemo resistance with their major key players of miRNAs and histone deacetylases (HDACs). As shown by own theoretical databank analysis, the crosstalk between miRNAs and HDACs are relevant in different human chronic diseases and cancerogenic pathways.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Swierczynski S, Klieser E, Urbas R, Stättner S, Primavesi F,

Keywords: Epigenetics, miRNA, histone deacetylases, pancreatic neuroendocrine tumor,

#220 The Global mTOR Inhibitor Torin1 is More Effective than the mTORC1 Inhibitor, Everolimus, Alone or in Combination with Histone Deacetylases Inhibitors, in Suppressing Neuroendocrine Tumors Cell Proliferation

Introduction: Torin1, a new mTOR inhibitor that globally inhibits both mTORC1 and mTORC2, seems to impair cell growth and proliferation to a greater degree than rapamycin; its effects in NET cells are unknown.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Grozinsky-Glasberg S, Rubinfeld H, Cohen O, Greif F, Kammer A,

Keywords: Torin1, RAD001, NETs, antiproliferation, Akt, mTOR, HDACi,